The 4th CAS/ESA/MPE collaboration workshop on Einstein Probe was held by video conferencing, on June. 15-17, 2021. Nearly 90 members participated in this conference. 25 scientific and technical staffs from the Einstein Probe project reported the latest progress of the project in the following areas including the development of the prototypes of the payloads (WXT and FXT), the test results of various experiments, the development of software development of ground application systems and ground support systems, and the simulation and optimization of the scientific goals. The participants have had full exchanges and discussions throughout the meeting, laying a good foundation for the following international cooperation of the project.